This can be solved with a simple `groupby` operations, which can tell you how often each combination appears. Then you just need to compare this with your `n` and filter the data:

    key = ["begin", "end", "case"]
    n = len(systems) // 2
    mask = df.groupby(key)["system"].count() > n
    df.set_index(key)[mask]\
      .reset_index()\
      .drop(columns="system")\
      .drop_duplicates()

    #    begin  end  case
    # 0     10   14  0365

This outputs the same as your code on my machine, but not the same as the example output you gave in your question (which I think is wrong).

Note that I used integer division `//` instead of float division `/` and manually casting to `int`.

In general, if you find yourself using `itertuples` in `pandas`, you should think very hard if you cannot achieve your goal in another way, as that is one of the slowest ways to do something with all rows of a dataframe.